The Journal of Practical Medicine ›› 2021, Vol. 37 ›› Issue (19): 2482-2486.doi: 10.3969/j.issn.1006⁃5725.2021.19.010

• Clinical Research • Previous Articles     Next Articles

Relationship between preoperative systemic immune inflammation index and postoperative prognosis of pa⁃ tients with pancreatic cancer

WAN Mengyuan，LIU Shujuan，LIU Jingjing，CUI Jing.   

  1. Department of Gastroen⁃ terology，the Second Affiliated Hospital，Zhengzhou University，Zhengzhou 450014，China

  • Online:2021-10-10 Published:2021-10-10
  • Contact: CUI Jing E⁃mail：cuijing717@163.com

Abstract:

Objective To investigate the effect of preoperative systemic immune inflammation index（SII） on postoperative prognosis of patients with pancreatic cancer（PDAC）. Methods The clinical data of PDAC patients who underwent pancreatic cancer resection in the second affiliated Hospital of Zhengzhou University from January 2015 to December 2020 were analyzed retrospectively，including general data（age，sex，underlying disease）and the results of laboratory examination one week before operation（blood routine，CA19⁃9，bilirubin level，tumor size，lymph node metastasis，tumor differentiation）. The SII of patients one week before operation was calculated according to the formula：the platelet count × the number of neutrophils/the number of lymphocytes. The best critical value of SII was determined by ROC curve，the survival curve was drawn by Kaplan⁃Meier，and the relationship between preoperative SII and postoperative survival was discussed by Cox univariate and multivariate regression analysis. Results This study included 150 patients，aged 42.0 ~ 79.0（60.4 ± 9.9）years，76 males（50.67%）and 74 females（49.33%）. According to the ROC curve，the best cut⁃off value of SII was 822，above which there were 71 cases and under which there were 79. By Kaplan⁃Meier curve，the 1，3，5⁃year survival rates of the two groups were（39.7%，5.7%，0.0%）and（71.8%，37.2%，2.1%），respectively，the average survival time was（14.88 ± 1.56）months and（29.92 ± 2.02）months，respectively，and the overall survival rate of the SII ≤ 822 group was significantly higher than that of the SII > 822 group（P < 0.05）. By Cox multivariate survival analysis，the indepen⁃ dent risk factors for their postoperative prognosis were SII > 822，tumor > 3 cm and lymph node metastasis（P < 0.05）. Conclusion The independent risk factors affecting the overall survival of pancreatic cancer patients are preoperative SII > 822，tumor > 3 cm and lymph node metastasis. The higher the SII，the worse the prognosis.

Key words:

pancreatic cancer, pancreatic ductal adenocarcinoma, systemic immune inflammatory index, prognosis